Gene information
Official symbol ALPL
Official full name alkaline phosphatase, biomineralization associated
Gene type protein-coding gene
Chromosome1p36.12
Alias symbolTNSALP|TNALP|TNAP
Previous symbolHOPS
Gene familyAlkaline phosphatases
Resources
Entrez Gene 249
HGNC HGNC:438
Ensembl ENSG00000162551
Vega OTTHUMG00000002949
UCSC uc001bet.4
GO terms: 33 records
GO Description Category LogP Number of genes Detail
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001503 ossification GO Biological Processes -16.3087139 28 More
GO:0001649 osteoblast differentiation GO Biological Processes -6.81659337 21 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0004035 alkaline phosphatase activity GO Molecular Functions -7.54005449 4 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0007568 aging GO Biological Processes -23.5429582 29 More
GO:0007584 response to nutrient GO Biological Processes -29.4823239 48 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0016788 hydrolase activity, acting on ester bonds GO Molecular Functions -4.57583420 56 More
GO:0016791 phosphatase activity GO Molecular Functions -2.41527592 10 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031225 anchored component of membrane GO Cellular Components -4.51589396 20 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031960 response to corticosteroid GO Biological Processes -20.1789519 26 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0042476 odontogenesis GO Biological Processes -9.69427751 24 More
GO:0042578 phosphoric ester hydrolase activity GO Molecular Functions -4.79997475 34 More
GO:0048545 response to steroid hormone GO Biological Processes -20.1914989 32 More
GO:0048705 skeletal system morphogenesis GO Biological Processes -7.04838258 29 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0051384 response to glucocorticoid GO Biological Processes -16.9609899 22 More
GO:0060348 bone development GO Biological Processes -12.2474877 36 More
GO:0060349 bone morphogenesis GO Biological Processes -6.25068095 17 More
GO:0110148 biomineralization GO Biological Processes -9.16361193 13 More
GO:0120161 regulation of cold-induced thermogenesis GO Biological Processes -19.1025541 38 More
GO:0120162 positive regulation of cold-induced thermogenesis GO Biological Processes -19.5569802 32 More
GO:0140657 ATP-dependent activity GO Molecular Functions -2.60810192 16 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa00730 Thiamine metabolism KEGG Pathway -4.45456766 4 More
hsa00790 Folate biosynthesis KEGG Pathway -3.46447442 4 More
Drug-Gene interaction
view
Related drugs: 27 records
Drug name Interaction type Source PMID View
(-)-epicatechin DTC view
cephalochromin DTC view
chembl1256783 DTC view
chembl1408276 DTC view
chembl146710 DTC view
chembl1731432 DTC view
chembl2094652 DTC view
chembl234338 DTC view
chembl260311 DTC view
chembl307893 DTC view
chembl505807 DTC view
chembl56393 DTC view
chembl585591 DTC view
chembl586135 DTC view
chembl598663 DTC view
chembl600956 DTC view
chembl81782 DTC view
dihydrodaphnodorin b DTC view
haematoxylin DTC view
isoquercetin DTC view
levamisole TTD view
myricetin DTC view
pyrogallol red DTC view
sulfuretin DTC view
terpyridine DTC view
thunberginol b DTC view
tyrphostin 23 DTC view
Related studies: 7 records
Molecular factor Omics type Application Objective MI type Reference
alkaline phosphatase proteomics myocardial infarction[diagnosis] myocardial infarction Park JB et al. Eur Heart J. 2013
alkaline phosphatase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Iqbal MP et al. Clin Chim Acta. 2013
alkaline phosphatase proteomics death[prognosis (bad)] acute myocardial infarction Nunes JP et al. Ann Transl Med. 2016
alkaline phosphatase proteomics major adverse cardiac and cerebral events[prognosis (bad)] acute ST elevation myocardial infarction Oh PC et al. PLoS One. 2017
alkaline phosphatase proteomics coronary slow flow phenomenon[prognosis (bad)] ST elevation myocardial infarction Edem E. J Int Med Res. 2018
alkaline phosphatase proteomics major adverse cardiac and cerebral events[prognosis (bad)] acute ST elevation myocardial infarction Oh PC et al. PLoS One. 2020
alkaline phosphatase proteomics vitamin D deficiency[prognosis (bad)] acute myocardial infarction Aleksova A et al. Int J Vitam Nutr Res. 2015
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